International Business Machines Corporation
Positional Delivery and Encoding by Oligonucleotides of Biological Cells for Single Cell Sequencing (POS SEQ)

Abstract:

Techniques for positional delivery and position encoding by oligonucleotides of biological cells for single cell RNA sequencing are provided. In one aspect, a method of positional delivery and encoding of cells in a biological sample includes: encoding the cells in the biological sample for single cell sequencing by delivering molecular probes inside the cells that encode a position of the cells in the biological sample. A system for positional delivery and encoding of cells in a biological sample is also provided.