International Business Machines Corporation
Accelerated pharmaceutical repurposing by finding anticorrelations and by text mining

Abstract:

Utilizing a computing device to assist in repurposing of a pharmaceutical. An identification of a pharmaceutical for repurposing study is received by a computing device. A pharmaceutical expression signature is retrieved based upon the identification of the pharmaceutical, the pharmaceutical expression signature indicating differential expressions of a plurality of biomolecules regulated by the pharmaceutical. A plurality of disease expression signatures are retrieved from a disease omics database, each disease expression signature indicating differential expressions of a plurality of biomolecules affected by a disease. A pharmaceutical vector is generated based upon the pharmaceutical expression signature for the pharmaceutical. A plurality of disease vectors are generated based upon the plurality of disease expression signatures for each disease. N hypotheses correlating the pharmaceutical vector and one or more of the plurality of disease vectors are generated, each hypothesis indicating a potential repurposing for the pharmaceutical to treat the disease.