Intercept Pharmaceuticals, Inc.
Methods and intermediates for the preparation of bile acid derivatives

Abstract:

The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I ##STR00001## or pharmaceutically acceptable salt, hydrate, solvate or amino acid, sulfate or glucuronide conjugate, or prodrug thereof, comprising the step of reacting a compound of formula I-4 with a halogenating reagent to provide a compound of formula I-5a ##STR00002##