Intercept Pharmaceuticals, Inc.
TGR5 MODULATORS AND METHODS OF USE THEREOF

Abstract:

The invention relates to compounds of Formula A: ##STR00001## or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.