Intercept Pharmaceuticals, Inc.
TGR5 modulators and methods of use thereof

Abstract:

The application relates to compounds of formula A: ##STR00001## or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.