IDEAYA Biosciences, Inc.
METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING LACTAM COMPOUNDS

Abstract:

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): ##STR00001## wherein the letters and symbols X.sup.1, X.sup.2, Z, R.sup.1b, R.sup.1c, R.sup.1d, R.sup.1e, R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.