IDEAYA Biosciences, Inc.
HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Abstract:

Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Pol.theta.) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Pol.theta. such as cancer, including homologous recombination (HR) deficient cancers. ##STR00001##