IDEAYA Biosciences, Inc.
ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Abstract:

Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Pol.theta.) inhibitors of Formula (I). ##STR00001## Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Pol.theta. such as cancer, including homologous recombination (HR) deficient cancers.