Illumina, Inc.
SYSTEMS AND METHODS FOR OUTLIER SIGNIFICANCE ASSESSMENT

Abstract:

Systems and methods are provided for identifying genes with outlier expression across multiple samples, including: at least one processor; and at least one non-transitory computer readable medium containing instructions that, when executed by the at least one processor, cause the at least one processor to perform operations including: receiving gene expression data of a plurality of samples, the samples comprising gene expression values corresponding to genes; standardizing the gene expression data using the median and median absolute deviation of each gene; determining a value of a distribution statistic for the standardized gene expression observations based on a probability of outlier gene expression data; determining a null distribution of the distribution statistic using the standardized gene expression data; and outputting a significance value of the genes across the multiple samples, the significance value based on the value of the distribution statistic and the null distribution.