I-Mab
MODIFIED CK AND CH1 DOMAINS

Abstract:

Provided are antibody and antigen-binding fragment with modified C.kappa. and CH1 domains that still enable pairing of the C.kappa. and CH1 domains but have reduced pairing compared to wild type CH1 and C.kappa. domains without the modification. Such modifications can particularly useful for preparing bispecific antibodies which two different pairs of C.kappa. and CH1 domains.