I-Mab
Anti-claudin 18.2 and anti-4-1BB bispecific antibodies and uses thereof
Last updated:
Abstract:
Provided are bispecific and multi-specific antibodies that target both claudin 18.2 (CLDN18.2) and 4-1BB. These antibodies, in the absence of CLDN18.2-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN18.2-expressing cells, however, these antibodies can trigger CLDN18.2-dependent 4-1BB signaling, leading to potent immune response to the CLDN18.2-expressing tumor cells.
Status:
Grant
Type:
Utility
Filling date:
12 Aug 2020
Issue date:
1 Mar 2022