Impel Pharmaceuticals Inc.
REPEATED ADMINISTRATION OF DIHYDROERGOTAMINE FOR TREATMENT OF FREQUENT MIGRAINE HEADACHES

Abstract:

Methods are provided for reducing the frequency of migraine attacks in a subject who has frequent migraine headaches with or without aura. The methods comprise intranasally administering to the subject a pharmaceutical composition comprising dihydroergotamine (DHE) or salt thereof on a repeat dose schedule, wherein each intranasal administration is delivered by a manually actuated, propellant-driven, metered-dose administration device, and wherein the schedule is a chronic intermittent schedule in which each of the repeated administrations is performed while the subject is experiencing a migraine headache.