Inhibrx Biosciences, Inc.
Polypeptides Comprising Modified IL-2 Polypeptides and Uses Thereof

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Abstract:

Provided herein are polypeptide comprising a modified IL-2, wherein the modified IL-2 has reduced affinity for the IL-2 receptor relative to wild type IL-2. In some embodiments, polypeptides comprising a modified IL-2 that bind and agonize activated T cells are provided. Uses of the polypeptides comprising a modified IL-2 are also provided.

Status:
Application
Type:

Utility

Filling date:

6 Jan 2020

Issue date:

24 Mar 2022