Insmed Incorporated
LIPO-GLYCOPEPTIDE CLEAVABLE DERIVATIVES AND USES THEREOF
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Abstract:
The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavable moiety that in certain embodiments, is designed to allow for cellular uptake and/or a more rapid clearance of the glycopeptide metabolite (i.e., the cleaved glycopeptide) from the site of administration (e.g., the lung) as compared to the uncleaved LGPC.
Status:
Application
Type:
Utility
Filling date:
10 Jun 2021
Issue date:
5 May 2022