Ionis Pharmaceuticals, Inc.
OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE

Abstract:

Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are described herein. In some embodiments, oligonucleotides comprising a stabilized phosphate moiety covalently attached to the 5'-terminal nucleoside are provided.