Keros Therapeutics, Inc.
ACTIVIN RECEPTOR TYPE IIB VARIANTS AND METHODS OF USE THEREOF
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Abstract:
The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and/or pulmonary hypertension.
Status:
Application
Type:
Utility
Filling date:
9 Jul 2020
Issue date:
31 Dec 2020