Karuna Therapeutics, Inc.
XANOMELINE DERIVATIVES AND METHODS FOR TREATING NEUROLOGICAL DISORDERS

Abstract:

Provided herein are compounds comprising compounds of formula I ##STR00001## and/or salts thereof; wherein at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, and R.sup.13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, and R.sup.23 are independently chosen from hydrogen and deuterium; with the proviso that when R.sup.1, R.sup.2, and R.sup.3 are fluorine, then at least one of R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, and R.sup.13 is fluorine or at least one of R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, and R.sup.23 is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.