Karuna Therapeutics, Inc.
COMPOSITIONS AND METHODS FOR TREATING DISORDERS AMELIORATED BY MUSCARINIC RECEPTOR ACTIVATION

Abstract:

Provided herein is a method of treating schizophrenia or a disease related to schizophrenia in a patient in need thereof. The method comprises orally administering to the patient twice daily an oral pharmaceutical composition comprising a plurality of xanomeline beads comprising xanomeline or a salt thereof, and plurality of trospium beads comprising a salt of trospium, via the titration scheme that comprises up-titration of the xanomeline, or a salt thereof, and the salt of trospium.