Karuna Therapeutics, Inc.
COMPOUNDS AND METHODS OF DEUTERATED XANOMELINE FOR TREATING NEUROLOGICAL DISORDERS

Abstract:

Provided herein are compounds of Formula I and/or salts thereof; wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22 and R.sup.23 are independently chosen from H and D. At least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.22 and R.sup.23 is enriched with deuterium, and R19, R20, and R21 are independently chosen from H and D; or two of R.sup.19, R.sup.20, and R.sup.21 are enriched with deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.