Kura Oncology, Inc.
METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS

Abstract:

The present invention relates to the field of molecular biology and cancer biology. Specifically, the present invention relates to methods of treating a KIR-mutant cancer in a subject with a farnesyltransferase inhibitor (FTI). The present invention also relates to methods of treating a subject with a farnesyltransferase inhibitor (FTI) that include determining whether the subject is likely to be responsive to the FTI treatment based on the mutation status of a member of the KIR family in the subject.