Laboratory Corporation of America Holdings
Methods and systems for predicting HIV-1 coreceptor tropism

Abstract:

The present methods for predicting coreceptor tropism may include obtaining the amino acid and/or nucleic acid sequence of at least a portion of the envelope or envelope coding region from a biological sample obtained from a subject; analyzing the amino acid sequence, nucleic acid sequence, or both of the portion of the envelope or envelope coding region using a case based reasoning analysis; and determining the coreceptor tropism. Also described are systems and computer readable media for utilizing the systems or performing the methods.