Laboratory Corporation of America Holdings
DEVICES AND METHODS TO REDUCE INTERFERING COMPOUNDS IN BIOLOGICAL SAMPLES

Abstract:

This disclosure provides devices and methods to reduce interfering compounds in biological samples. In one embodiment, disclosed is a device to reduce a target interfering compound in a biological sample comprising a binding agent attached to a solid support, the binding agent capable of binding a target interfering compound within the biological sample, wherein binding of the target interfering compound to the binding agent reduces the amount of target interfering compound in the biological sample. In other embodiments, provided is a method of reducing the amount of a target interfering compound in a biological sample comprising: adding a binding agent to the sample, wherein the binding agent binds the target interfering compound with a higher affinity than the binding agent binds to other components in the sample; incubating the sample to allow a complex to form between the binding agent and the target interfering compound; and removing the complexed target interfering compound that is bound to the binding agent.