Laboratory Corporation of America Holdings
Methods, Compositions and Systems for Detecting PNPLA3 Allelic Variants

Abstract:

Disclosed herein are methods and kits for detection of a single nucleotide polymorphism (SNP) rs738409 of a Patatin-like phospholipase domain containing 3 (PNPLA3) gene in a subject. Such methods are useful in the diagnosis of a subject with NASH and the selection of a particular treatment for the subject. In some embodiments, the provided methods allow for a highly selective detection of SNP rs738409.