Eli Lilly and Company
Methods for producing Fabs and bi-specific antibodies

Abstract:

The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (V.sub.H/V.sub.L) domain and the heavy chain-light chain constant (C.sub.H1/C.sub.L) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.