Eli Lilly and Company
KCNQ Potentiators

Abstract:

Small molecule potentiatiors to potassium channels (such as Kv7 potentiators--which are also called KCNQ potentiators), compositions including such compounds, and methods of using such compounds for the treatment of Amyotrophic Lateral Sclerosis and other neurological diseases caused by changes in motor neuron excitability, including, but not limited to, primary lateral sclerosis, pseudobulbar palsy, progressive bulbar palsy, progressive muscular atrophy and epilepsy.