Eli Lilly and Company
Methods for Producing Fabs and IgG Bispecific Antibodies

Abstract:

The present invention provides methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in C.sub.H1/C.sub.L interface, Fabs and IgG bi-specific antibodies produced according to said processes as well as nucleic acids, vectors and host cells encoding the same.