Liminal BioSciences Inc.
SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS

Abstract:

The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating bone remodeling, for stimulating the differentiation and mineralization of osteoblasts, for inhibiting bone resorption and for modulating serum level of adiponectin in a subject. These uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof, ##STR00001## wherein A is C.sub.5 alkyl, C.sub.6 alkyl, C.sub.5 alkenyl, C.sub.6 alkenyl, C(O)--(CH.sub.2).sub.n--CH.sub.3 or CH(OH)--(CH.sub.2).sub.n--CH.sub.3 wherein n is 3 or 4; R.sub.1 is H, F or OH; R.sub.2 is H, F, OH, C.sub.6 alkyl, C.sub.5 alkenyl, C.sub.6 alkenyl, C(O)(CH.sub.2).sub.n--CH.sub.3 or CH(OH)--(CH.sub.2).sub.n--CH.sub.3 wherein n is 3 or 4; R.sub.3 is H, F, OH or CH.sub.2Ph; R.sub.4 is H, F, or OH; Q is 1) (CH.sub.2).sub.mC(O)OH wherein m is 1 or 2, 2) CH(F)--C(O)OH, 3) CF.sub.2--C(O)OH, or 4) C(O)--C(O)OH.