Marrone Bio Innovations, Inc.
A METHOD FOR INCREASING ROMIDEPSIN PRODUCTION FROM FERMENTATION BROTH

Abstract:

The present invention includes a method to increase romidepsin concentration in a bacteria fermentation media. Romidepsin concentration in a fermentation is increased by adding, for example, copper sulfate. The end resulting romidepsin concentration is increased by at least about two fold as compare to fermentation without copper sulfate.