Madrigal Pharmaceuticals, Inc.
METHODS OF TREATING NEUROLOGICAL DISEASES AND DISORDERS

Abstract:

The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NF.kappa.B and/or the amount of I.kappa.B. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NF.kappa.B and/or the amount of I.kappa.B is materially unaltered.