Magenta Therapeutics, Inc.
ANTI-CD252 ANTIBODIES, CONJUGATES, AND METHODS OF USE

Abstract:

The invention provides methods of preventing and treating graft-versus-host-disease, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibodies, antibody fragments, and antibody-drug conjugates that specifically bind CD252. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.