Magenta Therapeutics, Inc.
COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD137+ CELLS

Last updated:

Abstract:

The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.

Status:
Application
Type:

Utility

Filling date:

21 Jan 2020

Issue date:

17 Sep 2020