Magenta Therapeutics, Inc.
Anti-CD45 Antibody Drug Conjugates and Uses Thereof

Last updated:

Abstract:

The invention provides anti-CD45 antibody drug conjugates (ADCs), and methods of use thereof. In one embodiment, the invention provides methods of depleting a population of CD45+ cells from a subject, by administration of an anti-CD45 ADC provided herein. In some embodiments, the ADCs include a cytotoxin containing a benzodiazepine moiety, for example. a pyrrolobenzodiazepine (PBD) or an indolinobenzodiazepine (IGN) moiety.

Status:
Application
Type:

Utility

Filling date:

22 Oct 2021

Issue date:

9 Jun 2022