Magenta Therapeutics, Inc.
ANTHRACYCLINE ANTIBODY-DRUG CONJUGATES AND USES THEREOF

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Abstract:

Antibody-drug conjugates (ADCs) comprising an anthracycline and an anti-CD117 antibody are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, are provided.

Status:
Application
Type:

Utility

Filling date:

21 Oct 2021

Issue date:

21 Jul 2022