Marinus Pharmaceuticals, Inc.
GANAXOLONE FOR USE IN TREATING GENETIC EPILEPTIC DISORDERS

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Abstract:

The disclosure provides a method of treating a mammal having a genetic epileptic disorder, comprising chronically administering a pharmaceutically acceptable pregnenolone neurosteroid to a mammal having a genetic epileptic disorder in an amount effective to reduce the seizure frequency in the mammal. In certain preferred embodiments, the mammal is a human patient who has a CDKL5 genetic mutation. In certain preferred embodiments, the patient has a low endogenous level of a neurosteroid(s). In certain preferred embodiments, the pregnenolone neurosteroid is ganaxolone.

Status:
Application
Type:

Utility

Filling date:

24 Mar 2022

Issue date:

11 Aug 2022