Mersana Therapeutics, Inc.
Protein-polymer-drug conjugates

Abstract:

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L.sup.D-D, the protein based recognition-molecule being connected to the polymeric carrier by L.sup.P. Each occurrence of D is independently an Auristatin compound. L.sup.D and L.sup.P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.