Navidea Biopharmaceuticals, Inc.
COMPOSITIONS AND RELATED METHODS FOR THE ABLATION OF M2 MACROPHAGES AND MYELOID DERIVED SUPPRESSOR CELLS

Abstract:

Compositions and methods for ablating CD206 expressing macrophages and/or CD206 expressing myeloid derived suppressor cells (MDSCs) are disclosed. In certain aspects, disclosed methods comprise administering to a subject in need thereof an effective dose of a compound comprising a dextran backbone and one or more CD206 targeting moieties and one or more therapeutic agents attached thereto. In certain aspects, the therapeutic agent comprises a metal. In further aspects, the therapeutic agent comprises a cytotoxic agent.