NuCana plc
PROCESS FOR PREPARING NUCLEOSIDE PRODRUGS

Last updated:

Abstract:

A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb.

Status:
Application
Type:

Utility

Filling date:

18 May 2021

Issue date:

3 Feb 2022