NuCana plc
PROCESS FOR PREPARING NUCLEOSIDE PRODRUGS
Last updated:
Abstract:
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb.
Status:
Application
Type:
Utility
Filling date:
18 May 2021
Issue date:
3 Feb 2022