NuCana plc
Synthesis of phosphate derivatives
Last updated:
Abstract:
The present invention is a process for the preparation of certain 5'-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2'-deoxyuridine-5'-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphat- e).
Status:
Grant
Type:
Utility
Filling date:
14 Jun 2018
Issue date:
16 Aug 2022