9 Meters Biopharma, Inc.
COMPOSITIONS AND METHODS FOR TREATING ULCERATIVE COLITIS

Abstract:

The invention, in various aspects and embodiments, provides compositions and methods for treating or managing ulcerative colitis (UC) (including mild or moderate UC), including intestinal and extraintestinal symptoms, including but not limited to arthritis. The compositions and methods in various embodiments relate to oral administration of pharmaceutical compositions that comprise an effective amount of one or more agents that forms at least one 4-APAA compound by azo reduction in the colon. In various embodiments, active agent is available for local action in the lumen of the large intestine. Further, as described herein, a significant portion of the 4-APAA formed by azo reduction in the large intestine is systemically available to ameliorate extraintestinal symptoms.