Novo Nordisk A/S
USE OF C5AR ANTAGONISTS

Abstract:

C5a and C5aR stimulate the inflammatory response and C5aR antagonist can counteract this function performing as a anti-inflammatory agents. This functionality is considered useful in treatment of inflammatory diseases including auto immune diseases. In addition it has been found that C5a and C5aR have a function in relation to bone homeostasis and remodelling and that C5aR antagonists are useful for treatment of bone damage, such as bone erosion and loss of bone density and for treatment of bone damage and cartilage damage