Novo Nordisk A/S
Glucose-sensitive albumin-binding derivatives

Abstract:

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X--R2, and wherein "X" is a mono- to multiatomic linker and where R.sup.1 and R.sup.2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'--R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.