Novartis AG
Salts and solid forms of a monobactam antibiotic

Abstract:

The invention provides new solid forms, salts and polymorphs of 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazoli- din-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cycloprop- anecarboxylic acid (referred to herein as Compound X), pharmaceutical compositions containing them, and processes for their manufacture and use in therapy.