Novartis AG
Heterocyclic compounds and methods of their use

Abstract:

The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT.sub.2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT.sub.2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.