Novartis AG
POLYA TAIL LENGTH ANALYSIS OF RNA BY MASS SPECTROMETRY

Abstract:

Described herein are methods of analyzing and producing RNA compositions, e.g., mRNA compositions, that include determining the amount of a polyA chain length and/or 5 the relative distribution of polyA chain lengths in a sample from the RNA composition using mass spectrometry, e.g., LC-MS or MALDI-MS.