Novartis AG
COMBINATION

Abstract:

A novel combination comprising a 17 .alpha.-hydroxylase/C17,20 lyase inhibitor, for example: (3.beta.)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol or a pharmaceutically acceptable salt or ester thereof, and an AKT inhibitor, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-m- ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of 17 .alpha.-hydroxylase/C17,20 lyase and/or AKT inhibition is beneficial, e.g., cancer.