Novartis AG
HIGH-THROUGHPUT MULTI-ORGAN PERFUSION MODELS

Abstract:

The invention provides a fluidic device that comprises at least two separate testing units, each of which is adapted to expose living cells to a moving fluid. The fluidic devices are useful for testing cell types such as kidney cells that are sensitive to shear stress, and can be configured for high-throughput testing. The fluidic device is adapted to receive a multi-well cell culture plate to which the living cells can be adhered or affixed. In some embodiments, flow channels in the fluidic device are positioned to expose the living cells to moving fluid, and the flow wells are adapted to provide substantially uniform shear stress across the area where the living cells are exposed to the moving fluid.