Orgenesis Inc.
THREE DIMENSIONAL CLUSTERS OF TRANSDIFFERENTIATED CELLS, COMPOSITIONS AND METHODS THEREOF

Abstract:

The present disclosure provides compositions and methods for providing a cell replacement therapy to treat various diseases, including pancreatic diseases and diabetes. Specifically, the disclosure provides three-dimensional (3D) cell clusters of transdifferentiated insulin producing cells attached to scaffolds, such as a polysaccharide matrix, in order to provide a cell replacement therapy.