Outlook Therapeutics, Inc.
Modulation of charge variants in a monoclonal antibody composition

Last updated:

Abstract:

Combinations of different chromatography modalities with particularly refined conditions significantly reduce acid charge variants in a preparation of monoclonal antibodies. The process for reducing acid charge variants utilizes a combination of anion exchange and hydrophobic interaction chromatography, followed by cation exchange chromatography polishing, whereby the levels of acidic or basic charge species of the monoclonal antibodies may be modulated to a desired level.

Status:
Grant
Type:

Utility

Filling date:

21 Jan 2016

Issue date:

30 Jun 2020