Pfizer Inc.
PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS

Abstract:

The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1) and boronates of Formula (2), stereoisomers thereof; ##STR00001## wherein Q is selected from the group consisting of --P(O)(OH).sub.2, --P(O)(OH)(O.sup.-M.sup.+), --P(O)(O.sup.-M.sup.+).sub.2 and --P(O)(O.sup.-).sub.2M.sup.2+; M.sup.+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M.sup.2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.