Pfizer Inc.
CALICHEAMICIN DERATIVES AND ANTIBODY DRUG CONJUGATES THEREOF

Abstract:

The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.